Variantes dos genes IRS1 e IRS2 associados a resistência à insulina e diabetes mellitus tipo 2: uma revisão integrativa

Abstract

Diabetes Mellitus is considered a public health problem in most countries, from the most developed to the least developed (OLIVEIRA, J.E.P.; MILECH, A, 2006), due to its high prevalence and high rates of morbidity and mortality. According to the International Diabetes Federation (IDF), there are more than 463 million cases worldwide, with approximately the majority of cases being people living in urban areas and of working age. It is predicted that by 2045, around 700 million people worldwide will have this disease. (IDF, 2019)