Análise quantitativa dos antígenos de superfície do vírus da hepatite B em portadores de hepatite B em associação com vírus da hepatite D no Amazonas

Abstract

This is a study to examine the HBsAg levels in patients with Hepatitis B in association with the hepatitis D virus in the Amazon Background & Aims. There are an estimated 400 million chronic carriers of hepatitis B virus in the world, and in Brazil, mostly in the amazon region with 5 to 15% prevalence of HBV infection, and 15-20 million of these individuals may be co-infected or super-infected with HDV. Studies suggest quantitative HBsAg in combination with HBV-DNA as a diagnostic tool, prognostic and a predictive marker for antiviral therapy. It is a cross-sectional study, a descriptive case series evaluating the concentrations of quantitative HBsAg in the natural history of patients with HBV infection in association with HDV. We analyzed demographic data and laboratory tests performed to determine the concentrations of ALT, viral load, HBeAg status and HBsAg quantitative of 48 patients. There was no difference between the sexes. There was a predominance of young adults. The stage of the disease had a higher incidence was low replication, and immune tolerance phase that was held the highest average quantity of HBsAg. There is statistically significant association between the HBeAg and anti-HDV. There were more among HBeAg-negative patients co-infected than in mono-infected. There was no statistically significant association between quantitative HBsAg and ALT, HBsAg quantitative and viral load and HBsAg quantitative and HBeAg status. There is a significant association between anti-HDV. and HBV viral load levels. The HBsAg quantitative is higher in the phase of immunotolerance. There is high prevalence of co-infection HBV/HDV in the state of Amazonas. This disease seems to be related to inhibition of HBV replication and the quantitative HBsAg level. Keywords: HBeAg; Quantitative HBsAg; Hepatitis Delta; Amazonas.