Análise metabolômica de espécies de annonaceae ocorrentes em Manaus por meio de espectrometria de massas

Abstract

A medicinal plant is considered like any species that administered to man or animal, by any means or form, exerts some therapeutic function and due to the great use of these herbs, studies in search of their chemical substances were and are carried out continuously. The Annonaceae family is widely known for its alkaloids that are present in several species, however, there are still specimens whose chemical components have not been fully elucidated. Thus, the aim of this study was to comparatively recognize different species of plants from the Annonaceae family by means of mass spectrometry. For this, five plant species belonging to the genus Annona, Duguetia, Fusaea, Guatteria and Xylopia were collected, their extracts were obtained and analyzed by Liquid Chromatography coupled to High Resolution Mass Spectrometry (LC-HRMS/MS). Of the five plants, only the leaves of the species Guatteria discolor were analyzed and the results presented showed the presence of four alkaloid substances (puterine, oxoputerine, asimilobine and anonaine), the latter two being unpublished for this species. Among the identified molecules, only puterine has not yet had its biological activity elucidated, thus suggesting new studies for this substance. Keywords: Annonaceae, alkaloids, Guatteria discolor, aporphinic and oxoaporphinic.